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The Gastrointestinal System

The Gastrointestinal System at a Glance SATISH KESHAV The Gastrointestinal System at a Glance The Gastrointestinal System at a Glance SATISH KESHAV MBBCh (Wits), DPhil(Oxon), MRCP (UK) Consultant Gastroenterologist Director, Centre for Gastroenterology Royal Free and University College Medical School University College London Rowland Hill Street London NW3 2PF Blackwell Science © 2004 by Blackwell […]

Gene Mapping Goes from FISH to Surfing the Net

1 Gene  Mapping  Goes  from  FISH  to  Surfing  the  Net John  Valdes  and  Danilo  A. Tagle 1.  Introduction The amval  of  the second millenmum  will  usher m unsurpassed information and  knowledge  of  our  genetic constitution,  and will  promise  to revolutronize basic research  and molecular  medicine.  The  road  toward  a  complete  under- standing  of  our  genetic  […]

4 The History and Clinical Examination

4 The History and Clinical Examination The Massachusetts General Hospital Handbook of Pain Management 4 The History and Clinical Examination Jan Slezak and Asteghik Hacobian To each his suff’rings: all are men, Condemn’d alike to groan, The tender for another’s pain, Th’ unfeeling for his own. —Thomas Gray, 1716–1771 I. Patient interview 1. Pain history […]

3 The Placebo Effect

3 The Placebo Effect The Massachusetts General Hospital Handbook of Pain Management 3 The Placebo Effect Brian W. Dubois and Paul J. Christo Impatient at being kept awake by pain, I availed myself of the stoical means of concentration upon some indifferent object of thought, such as for instance the name of “Cicero” with its […]

CHAPTER 89 THE ACQUIRED IMMUNODEFICIENCY SYNDROME

CHAPTER 89 THE ACQUIRED IMMUNODEFICIENCY SYNDROME Williams Hematology CHAPTER 89 THE ACQUIRED IMMUNODEFICIENCY SYNDROME HOWARD A. LIEBMAN TIMOTHY P. COOLEY ALEXANDRA M. LEVINE Definition and History Definition Origins of HIV Etiology and Pathogenesis Human Immunodeficiency Virus-1 Pathogenesis of HIV Infection Diagnosis of HIV Infection Laboratory Features of Disease Progression Course and Prognosis Acute Retroviral Syndrome […]

CHAPTER 62 THE HEMATOLOGIC ASPECTS OF PORPHYRIA

CHAPTER 62 THE HEMATOLOGIC ASPECTS OF PORPHYRIA Williams Hematology CHAPTER 62 THE HEMATOLOGIC ASPECTS OF PORPHYRIA SHIGERU SASSA Definition and History Etiology and Pathogenesis Heme Control of Heme Synthesis in the Liver and Erythroid Cells Erythropoietic Porphyrias Congenital Erythropoietic Porphyria (CEP) Erythropoietic Protoporphyria Hepatic Porphyrias Acute Hepatic Porphyrias Chronic Hepatic Porphyrias Chapter References The porphyrias […]

CHAPTER 46 THE THALASSEMIAS

CHAPTER 46 THE THALASSEMIAS Williams Hematology CHAPTER 46 THE THALASSEMIAS DAVID J. WEATHERALL Definitions and History Different Forms of Thalassemia Etiology and Pathogenesis Genetic Control and Synthesis of Hemoglobin Globin Gene Clusters Molecular Basis of the Thalassemias Pathophysiology Imbalanced Globin-Chain Synthesis Persistent Fetal Hemoglobin Production and Cellular Heterogeneity Consequences of Compensatory Mechanisms for the Anemia […]

CHAPTER 37 THE MEGALOBLASTIC ANEMIAS

CHAPTER 37 THE MEGALOBLASTIC ANEMIAS Williams Hematology CHAPTER 37 THE MEGALOBLASTIC ANEMIAS BERNARD M. BABIOR General Considerations Definition Etiology and Pathogenesis Clinical Features Laboratory Features Folic Acid Deficiency Etiology and Pathogenesis Clinical Features Laboratory Features Differential Diagnosis Nonhematologic Effects of Folate Deficiency Therapy, Course, and Prognosis Cobalamin Deficiency Etiology and Pathogenesis Clinical Features Laboratory Features […]

CHAPTER 19 THE OPTIC CHIASM IN ENDOCRINOLOGIC DISORDERS

CHAPTER 19 THE OPTIC CHIASM IN ENDOCRINOLOGIC DISORDERS Principles and Practice of Endocrinology and Metabolism CHAPTER 19 THE OPTIC CHIASM IN ENDOCRINOLOGIC DISORDERS R. MICHAEL SIATKOWSKI AND JOEL S. GLASER Anatomy and Embryology of the Optic Chiasm Clinical Manifestations of Chiasmal Syndromes Vision Changes Headache Sensory Phenomena Eye Movement Disorders Pallor of the Optic Discs […]

9.11 The transmissible spongiform encephalopathies

9.11 The transmissible spongiform encephalopathies Oxford Textbook of Public Health 9.11 The transmissible spongiform encephalopathies Stephen Palmer, Charles Hillier, and Roland Salmon Introduction Animal TSEs Scrapie Transmissible mink encephalopathy Chronic wasting disease Bovine spongiform encephalopathy Spongiform encephalopathy in exotic ungulates Feline spongiform encephalopathy Human TSEs Kuru Creutzfeldt–Jakob disease Possible sources of sporadic CJD Variant Creutzfeldt–Jakob […]