Tag Archive | Sarcoidosis


167 SARCOIDOSIS Harrison’s Manual of Medicine 167 SARCOIDOSIS Definition Pathophysiology Clinical Manifestations Evaluation Diagnosis Outcome Bibliography Definition A systemic granulomatous disease of unknown etiology. Affected organs are characterized by an accumulation of T lymphocytes and mononuclear phagocytes, noncaseating epithelioid granulomas, and derangements of normal tissue architecture. Pathophysiology Mononuclear cells, mostly T helper lymphocytes and mononuclear […]

Chapter 175 – Sarcoidosis

Chapter 175 – Sarcoidosis   CLAUDE L. COWAN JR.           DEFINITION • A multisystem inflammatory disorder characterized histologically by the presence of noncaseating granulomas.   KEY FEATURES • Anterior and posterior uveitis. • Bilateral hilar lymphadenopathy and/or pulmonary parenchymal disease.   ASSOCIATED FEATURES • Cutaneous lesions. • Neurological abnormalities, including optic […]