Hematology

CHAPTER 134 FIBRINOLYTIC THERAPY

CHAPTER 134 FIBRINOLYTIC THERAPY Williams Hematology CHAPTER 134 FIBRINOLYTIC THERAPY JOSEPH LOSCALZO Plasminogen Activators Currently Available Agents Endogenous Agents Thrombolytic Therapy Monitoring Thrombolytic Therapy Clinical Thrombolytic Regimens Shortcomings of Thrombolytic Therapy Adjunctive Therapy for Fibrinolysis Chapter References Fibrinolytic therapy is designed to facilitate thrombolysis and thus decrease the ischemic damage produced by thrombotic events. Currently […]

CHAPTER 133 HEPARIN, HIRUDIN, AND RELATED AGENTS

CHAPTER 133 HEPARIN, HIRUDIN, AND RELATED AGENTS Williams Hematology CHAPTER 133 HEPARIN, HIRUDIN, AND RELATED AGENTS GARY E. RASKOB RUSSELL D. HULL GRAHAM F. PINEO Heparin Pharmacology Laboratory Monitoring of Therapy Clinical Use Antidote to Heparin LMW Heparin Pharmacology Clinical Use Danaparoid Pharmacology Clinical Use Hirudin and Derivatives Pharmacology Clinical Use Small-Molecule Direct Thrombin Inhibitors […]

CHAPTER 132 ORAL ANTICOAGULATION

CHAPTER 132 ORAL ANTICOAGULATION Williams Hematology CHAPTER 132 ORAL ANTICOAGULATION SAM SCHULMAN History Vitamin K Antagonists Chemistry and Mode of Action Pharmacokinetics Dosing Monitoring Interactions Complications of Therapy Lactation Surgical Management Indications Novel Vitamin K Antagonists Other Oral Anticoagulants Glycosaminoglycans Inhibitors of Coagulation Factor XA Inhibitors of Thrombin Chapter References The original and principal oral […]

CHAPTER 131 ANTIPLATELET THERAPY

CHAPTER 131 ANTIPLATELET THERAPY Williams Hematology CHAPTER 131 ANTIPLATELET THERAPY HARVEY J. WEISS Antiplatelet Drugs Aspirin Inhibitors of Thromboxane A2 Synthesis or Binding Prostaglandin I2 and Analogues Dipyridamole Ticlopidine and Clopidogrel Inhibitors of the Platelet GPIIB/IIIA Receptor Other Antiplatelet Agents Antiplatelet Drugs in Clinical Medicine Ischemic Heart Disease Valvular Heart Disease Cerebrovascular Disease Peripheral Vascular […]

CHAPTER 130 ATHEROSCLEROSIS, THROMBOSIS, AND CORONARY ARTERY DISEASE

CHAPTER 130 ATHEROSCLEROSIS, THROMBOSIS, AND CORONARY ARTERY DISEASE Williams Hematology CHAPTER 130 ATHEROSCLEROSIS, THROMBOSIS, AND CORONARY ARTERY DISEASE MARK B. TAUBMAN Introduction: Coronary Artery Disease and Thrombosis Clinical Presentations of Coronary Artery Disease Pathophysiology of Atherosclerotic Disease Classification of Atherosclerotic Plaques Animal Models of Atherosclerosis Response-to-Injury Model of Atherosclerosis Thrombosis and Plaque Rupture Models of […]

CHAPTER 129 VENOUS THROMBOSIS

CHAPTER 129 VENOUS THROMBOSIS Williams Hematology CHAPTER 129 VENOUS THROMBOSIS GARY E. RASKOB RUSSELL D. HULL GRAHAM F. PINEO Definition and History Etiology and Pathogenesis Clinical Features Laboratory Features Differential Diagnosis Differential Diagnosis of Deep-Vein Thrombosis Objective Testing for Deep-Vein Thrombosis Differential Diagnosis of Pulmonary Embolism Objective Testing for Pulmonary Embolism Therapy, Course, and Prognosis […]

CHAPTER 128 LUPUS ANTICOAGULANTS AND RELATED DISORDERS

CHAPTER 128 LUPUS ANTICOAGULANTS AND RELATED DISORDERS Williams Hematology CHAPTER 128 LUPUS ANTICOAGULANTS AND RELATED DISORDERS JACOB H. RAND Definition and History Definition History Etiology and Pathogenesis Etiology Pathogenesis Clinical Features Systemic Vascular Thrombosis Lupus and Other Autoimmune Conditions Stroke and Other Neurologic Conditions Catastrophic APL Syndrome Pregnancy Losses, Obstetrical Complications, and Infertility Bleeding Cutaneous […]

CHAPTER 127 HEREDITARY THROMBOPHILIA

CHAPTER 127 HEREDITARY THROMBOPHILIA Williams Hematology CHAPTER 127 HEREDITARY THROMBOPHILIA SCOTT H. GOODNIGHT JOHN H. GRIFFIN Introduction Major Hereditary Defects Hereditary Resistance to Activated Protein C Prothrombin G20210A Gene Polymorphism Hyperhomocysteinemia Protein C Deficiency Protein S Deficiency Antithrombin Deficiency High Levels of Factor VIII and Other Coagulation Factors Hereditary Thrombotic Dysfibrinogenemia Other Potential Thrombophilic Disorders […]

CHAPTER 126 DISSEMINATED INTRAVASCULAR COAGULATION

CHAPTER 126 DISSEMINATED INTRAVASCULAR COAGULATION Williams Hematology CHAPTER 126 DISSEMINATED INTRAVASCULAR COAGULATION URI SELIGSOHN Definition and History Etiology and Pathogenesis Pathology Pathogenesis Clinical Features Bleeding Thrombosis and Thromboembolism Shock Renal Dysfunction Liver Dysfunction Central Nervous System Dysfunction Pulmonary Dysfunction Mortality Laboratory Features Acute DIC Chronic DIC DIC Accompanied by Primary Fibrino(geno)lysis Primary Fibrinogenolysis Therapy Management […]

CHAPTER 125 HEMOSTATIC DYSFUNCTION RELATED TO LIVER DISEASES AND LIVER TRANSPLANTATION

CHAPTER 125 HEMOSTATIC DYSFUNCTION RELATED TO LIVER DISEASES AND LIVER TRANSPLANTATION Williams Hematology CHAPTER 125 HEMOSTATIC DYSFUNCTION RELATED TO LIVER DISEASES AND LIVER TRANSPLANTATION EBERHARD F. MAMMEN Introduction Hemostatic Defects in Chronic Liver Disease Bleeding Manifestations Pathogenesis Laboratory Features Therapy Liver Transplantation Chapter References Liver diseases are frequently associated with hemostatic derangements that can lead […]