Hematology

CHAPTER 144 THERAPEUTIC HEMAPHERESIS: INDICATIONS, EFFICACY,

CHAPTER 144 THERAPEUTIC HEMAPHERESIS: INDICATIONS, EFFICACY, COMPLICATIONS Williams Hematology CHAPTER 144 THERAPEUTIC HEMAPHERESIS: INDICATIONS, EFFICACY, COMPLICATIONS BRUCE C. MCLEOD Introduction Cell Depletion Plateletpheresis Leukapheresis Blood Component Exchanges Physiology Plasma Exchange Red Cell Exchange Chapter References Therapeutic hemapheresis provides a means to rapidly alter the composition of components of the blood. It can be a valuable […]

CHAPTER 143 PREPARATION AND CLINICAL USE OF PLASMA AND PLASMA FRACTIONS

CHAPTER 143 PREPARATION AND CLINICAL USE OF PLASMA AND PLASMA FRACTIONS Williams Hematology CHAPTER 143 PREPARATION AND CLINICAL USE OF PLASMA AND PLASMA FRACTIONS KENNETH D. FRIEDMAN JAY E. MENITOVE Preparation and Fractionation of Plasma Components and Derivatives Plasma Components Fresh-Frozen Plasma Plasma Frozen within 24 h of Collection Liquid Plasma Cryo-Poor Plasma Solvent-Detergent–Treated Plasma […]

CHAPTER 142 PRESERVATION AND CLINICAL USE OF PLATELETS

CHAPTER 142 PRESERVATION AND CLINICAL USE OF PLATELETS Williams Hematology CHAPTER 142 PRESERVATION AND CLINICAL USE OF PLATELETS SCOTT MURPHY Introduction Techniques for Platelet Preparation Whole-Blood-Derived Platelet Concentrates Apheresis Platelet Concentrates Storage of Platelet Concentrates Liquid Storage at 20 to 24°C Frozen Storage Fresh Whole Blood Lyophilized Platelets, Platelet Membranes, and Platelet Substitutes Clinical Response […]

CHAPTER 141 COLLECTION AND TRANSFUSION OF LEUKOCYTES, DENDRITIC CELLS, AND STEM CELLS

CHAPTER 141 COLLECTION AND TRANSFUSION OF LEUKOCYTES, DENDRITIC CELLS, AND STEM CELLS Williams Hematology CHAPTER 141 COLLECTION AND TRANSFUSION OF LEUKOCYTES, DENDRITIC CELLS, AND STEM CELLS NICHOLAS BANDARENKO MARK E. BRECHER History of Granulocyte Transfusion Preclinical Studies of Dogs with Granulocyte Transfusion Clinical Experience with Granulocyte Transfusion Granulocyte Concentrates from CML Donors Controlled Trials of […]

CHAPTER 140 PRESERVATION AND CLINICAL USE OF ERYTHROCYTES AND

CHAPTER 140 PRESERVATION AND CLINICAL USE OF ERYTHROCYTES AND WHOLE BLOOD Williams Hematology CHAPTER 140 PRESERVATION AND CLINICAL USE OF ERYTHROCYTES AND WHOLE BLOOD ERNEST BEUTLER Principles of Storage and Preservation of Blood Liquid Preservation of Erythrocytes Additive Solutions Frozen Storage of Erythrocytes Whole Blood Preparations ACD (Acid-Citrate-Dextrose), CPD (Citrate-Phosphate-Dextrose), and CPDA-1 (CPD with Adenine) […]

CHAPTER 139 BLOOD PROCUREMENT AND SCREENING

CHAPTER 139 BLOOD PROCUREMENT AND SCREENING Williams Hematology CHAPTER 139 BLOOD PROCUREMENT AND SCREENING JEFFREY McCULLOUGH An Overview of the Blood Banking System The System in the United States International Practices Plasma Derivatives Recruitment of Blood Donors Whole-Blood Donor Screening Medical History Physical and Laboratory Examination of the Blood Donor Collection of Whole Blood Blood […]

CHAPTER 138 HUMAN LEUKOCYTE AND PLATELET ANTIGENS

CHAPTER 138 HUMAN LEUKOCYTE AND PLATELET ANTIGENS Williams Hematology CHAPTER 138 HUMAN LEUKOCYTE AND PLATELET ANTIGENS KAREN A. SULLIVAN THOMAS J. KIPPS Human Leukocyte Antigens Definition Biochemistry Structure Tissue Distribution Function of the Human Leukocyte Antigens Genetics of the Major Histocompatibility Complex Nomenclature HLA Typing Inheritance of HLA Antigens Clinical Applications Platelet Antigens Platelet Alloantigens […]

CHAPTER 137 ERYTHROCYTE ANTIGENS AND ANTIBODIES

CHAPTER 137 ERYTHROCYTE ANTIGENS AND ANTIBODIES Williams Hematology CHAPTER 137 ERYTHROCYTE ANTIGENS AND ANTIBODIES LONI CALHOUN LAWRENCE D. PETZ Definitions and History Blood Group Systems Abo Blood Group System Rh Blood Group System Other Blood Group Systems General Immunology of Blood Group Antigens Antigen Expression Immunogenicity Biochemistry of Erythrocyte Antigens Carbohydrate Antigens Protein Antigens Effect […]

CHAPTER 136 DISORDERS OF FIBRINOLYSIS AND USE OF ANTIFIBRINOLYTIC AGENTS

CHAPTER 136 DISORDERS OF FIBRINOLYSIS AND USE OF ANTIFIBRINOLYTIC AGENTS Williams Hematology CHAPTER 136 DISORDERS OF FIBRINOLYSIS AND USE OF ANTIFIBRINOLYTIC AGENTS FEDOR BACHMANN Introduction Pharmacology of Antifibrinolytic Agents Mode of Action Pharmacokinetics Adverse Effects Clinical Use of Antifibrinolytic Agents Systemic Hyperfibrin(ogen)olysis Localized Fibrinolysis with Abnormal Hemostasis Localized Fibrinolysis with Normal Hemostasis Chapter References Under […]

CHAPTER 135 VON WILLEBRAND DISEASE

CHAPTER 135 VON WILLEBRAND DISEASE Williams Hematology CHAPTER 135 VON WILLEBRAND DISEASE DAVID GINSBURG Definition and History Etiology and Pathogenesis The Von Willebrand Factor Gene and Cdna Von Willebrand Factor Biosynthesis The Function of Von Willebrand Factor Molecular Genetics of Von Willebrand Disease Clinical Features Inheritance Clinical Symptoms Laboratory Features Bleeding Time Factor VIII Von […]