Archive | January 2012

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CHAPTER 101 PATHOLOGY OF MALIGNANT LYMPHOMAS

CHAPTER 101 PATHOLOGY OF MALIGNANT LYMPHOMAS Williams Hematology CHAPTER 101 PATHOLOGY OF MALIGNANT LYMPHOMAS PETER M. BANKS Definition and History Contribution of Immunology to Lymphoma Classification The Revised European-American Lymphoma (REAL) Classification Major Predictive Groupings of Non-Hodgkin Lymphoma Low-Grade Intermediate Grade High-Grade Hodgkin Lymphoma Nodular Lymphocyte-Predominance Hodgkin Lymphoma Classical Hodgkin Lymphoma Lymphocyte-Rich Type Mixed Cellularity […]

CHAPTER 100 LARGE GRANULAR LYMPHOCYTIC LEUKEMIA

CHAPTER 100 LARGE GRANULAR LYMPHOCYTIC LEUKEMIA Williams Hematology CHAPTER 100 LARGE GRANULAR LYMPHOCYTIC LEUKEMIA THOMAS P. LOUGHRAN MARSHALL E. KADIN Definition and History Etiology and Pathogenesis Clinical Features Laboratory Features Hematologic Findings Immunophenotyping Immune Abnormalities Histopathologic Features Differential Diagnosis Therapy, Course, and Prognosis Chapter References Clonal diseases of larger granular lymphocytes (LGL) can arise from […]

CHAPTER 99 HAIRY-CELL LEUKEMIA

CHAPTER 99 HAIRY-CELL LEUKEMIA Williams Hematology CHAPTER 99 HAIRY-CELL LEUKEMIA ALAN SAVEN Definition and History Etiology and Pathogenesis Clinical Features Laboratory Features Blood Marrow Spleen and Other Sites Cytochemistry Electron Microscopy Immunophenotype Immunohistochemistry Differential Diagnosis Therapy, Course, and Prognosis Therapy Course and Prognosis Chapter References Hairy-cell leukemia is a rare chronic lymphoproliferative disorder of B-lymphocytes […]

CHAPTER 98 CHRONIC LYMPHOCYTIC LEUKEMIA AND RELATED DISEASES

CHAPTER 98 CHRONIC LYMPHOCYTIC LEUKEMIA AND RELATED DISEASES Williams Hematology CHAPTER 98 CHRONIC LYMPHOCYTIC LEUKEMIA AND RELATED DISEASES THOMAS J. KIPPS Chronic Lymphocytic Leukemia Definition and History Etiology and Pathogenesis Clinical Features Patient Population General Symptoms Lymphadenopathy Splenomegaly and Hepatomegaly Extranodal Involvement Laboratory Features Blood Findings Marrow Findings Lymph Node Findings Immunologic Studies Differential Diagnosis […]

CHAPTER 97 ACUTE LYMPHOBLASTIC LEUKEMIA

CHAPTER 97 ACUTE LYMPHOBLASTIC LEUKEMIA Williams Hematology CHAPTER 97 ACUTE LYMPHOBLASTIC LEUKEMIA CHING-HON PUI Definition and History Etiology and Pathogenesis Incidence Risk Factors Acquired Genetic Changes Clinical Features Signs and Symptoms Physical Findings Laboratory Features Diagnosis and Cell Classification Differential Diagnosis Therapy Supportive Care Antileukemic Therapy Course and Prognosis Relapse Treatment Sequelae Prognostic Factors Chapter […]

CHAPTER 96 CLASSIFICATION OF MALIGNANT LYMPHOID DISORDERS

CHAPTER 96 CLASSIFICATION OF MALIGNANT LYMPHOID DISORDERS Williams Hematology CHAPTER 96 CLASSIFICATION OF MALIGNANT LYMPHOID DISORDERS THOMAS J. KIPPS Classification Associated Clinical Syndromes Abnormal Production of Immunoglobulin Marrow and Other Tissue Infiltration Lymphokine-Induced Disorders Systemic Symptoms Metabolic Signs Organ Infiltration (Extranodal Involvement) Chapter References This chapter outlines the category of neoplastic or pre-neoplastic lymphocyte and […]

CHAPTER 95 IDIOPATHIC MYELOFIBROSIS (AGNOGENIC MYELOID METAPLASIA)

CHAPTER 95 IDIOPATHIC MYELOFIBROSIS (AGNOGENIC MYELOID METAPLASIA) Williams Hematology CHAPTER 95 IDIOPATHIC MYELOFIBROSIS (AGNOGENIC MYELOID METAPLASIA) MARSHALL A. LICHTMAN Definition and History Etiology and Pathogenesis Clonal Hemopathy Fibroplasia Extramedullary Hematopoiesis Clinical Features Age and Sex Presenting Symptoms Presenting Signs Special Clinical Features Laboratory Features Blood Cell Counts and Morphology Functional Abnormalities of Blood Cells Marrow […]

CHAPTER 94 CHRONIC MYELOGENOUS LEUKEMIA AND RELATED DISORDERS

CHAPTER 94 CHRONIC MYELOGENOUS LEUKEMIA AND RELATED DISORDERS Williams Hematology CHAPTER 94 CHRONIC MYELOGENOUS LEUKEMIA AND RELATED DISORDERS MARSHALL A. LICHTMAN JANE L. LIESVELD Definition and History Etiology Pathogenesis Origin From A Stem Cell Clone Pluripotential Versus Hematopoietic Stem Cell Lesion Etiologic Role of the Ph Chromosome Coexistence of Normal Stem Cells Progenitor Cell Characteristics […]

CHAPTER 93 ACUTE MYELOGENOUS LEUKEMIA

CHAPTER 93 ACUTE MYELOGENOUS LEUKEMIA Williams Hematology CHAPTER 93 ACUTE MYELOGENOUS LEUKEMIA MARSHALL A. LICHTMAN JANE L. LIESVELD Definition and History Etiology and Pathogenesis Environmental Factors Evolution From a Chronic Clonal Hemopathy Predisposing Diseases Pathogenesis Mode of Inheritance Epidemiology Classification Clinical Features Signs and Symptoms Laboratory Features Blood Cell Findings Marrow Findings Plasma Chemical Findings […]

CHAPTER 92 MYELODYSPLASTIC DISORDERS (INDOLENT CLONAL MYELOID DISEASES AND OLIGOBLASTIC LEUKEMIA)

CHAPTER 92 MYELODYSPLASTIC DISORDERS (INDOLENT CLONAL MYELOID DISEASES AND OLIGOBLASTIC LEUKEMIA) Williams Hematology CHAPTER 92 MYELODYSPLASTIC DISORDERS (INDOLENT CLONAL MYELOID DISEASES AND OLIGOBLASTIC LEUKEMIA) MARSHALL A. LICHTMAN JAMES K. BRENNAN Definition and History History Classification Etiology and Pathogenesis Etiology Pathogenesis Clinical Features Incidence by Age, Sex, and Familial Occurrence Symptoms and Signs Special Clinical Features […]