Archive | January 2012

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CHAPTER 111 PLATELET MORPHOLOGY, BIOCHEMISTRY AND FUNCTION

CHAPTER 111 PLATELET MORPHOLOGY, BIOCHEMISTRY AND FUNCTION Williams Hematology CHAPTER 111 PLATELET MORPHOLOGY, BIOCHEMISTRY AND FUNCTION LESLIE V. PARISE SUSAN S. SMYTH BARRY S. COLLER Platelet Morphology and Biochemistry Light Microscopic Appearance Electron Microscopic Appearance and Biochemistry Platelet Physiology and Biochemistry Overview of Platelet Adhesion, Aggregation, and Platelet Thrombus Formation Platelet Energy Metabolism Platelet Contractile […]

CHAPTER 110 MEGAKARYOPOIESIS AND THROMBOPOIESIS

CHAPTER 110 MEGAKARYOPOIESIS AND THROMBOPOIESIS Williams Hematology CHAPTER 110 MEGAKARYOPOIESIS AND THROMBOPOIESIS DAVID J. KUTER Anatomy of Megakaryocytes Polyploidy Megakaryocyte Granules Megakaryocyte Surface Membrane Light Microscopic Appearance of Megakaryocytes The Origin of Megakaryocytes Early Megakaryocyte Progenitors Late Megakaryocyte Progenitors Effects of Thrombopoietic Growth Factors Platelet Production and Release The Formation of Platelets from Megakaryocytes Regulation […]

CHAPTER 109 HEAVY-CHAIN DISEASES

CHAPTER 109 HEAVY-CHAIN DISEASES Williams Hematology CHAPTER 109 HEAVY-CHAIN DISEASES JOEL N. BUXBAUM ALICE ALEXANDER Definition and History Etiology and Pathogenesis Chronic Antigenic Stimulation Defective Immunoglobulin Molecules Clinical Features Gamma-Heavy-Chain Disease Alpha-Heavy-Chain Disease Mu-Heavy-Chain Disease Delta- and Epsilon-Heavy-Chain Disease Laboratory Features Detection of Abnormal Immunoglobulin Protein Therapy, Course, and Prognosis Gamma-Heavy-Chain Disease Alpha-Heavy-Chain Disease Mu-Heavy-Chain […]

CHAPTER 108 WALDENSTRÖM MACROGLOBULINEMIA

CHAPTER 108 WALDENSTRÖM MACROGLOBULINEMIA Williams Hematology CHAPTER 108 WALDENSTRÖM MACROGLOBULINEMIA THOMAS J. KIPPS Definition and History Lymphoplasmacytic Neoplasms B-Lymphocytic Neoplasms Essential Monoclonal Macroglobulinemia Etiology and Pathogenesis Etiology Pathogenesis Clinical Features The Hyperviscosity Syndrome Laboratory Findings Serum Immunoglobulin and Blood Viscosity Blood and Marrow Cells Disorders of Hemostasis Renal Abnormalities Differential Diagnosis Therapy, Course, and Prognosis […]

CHAPTER 107 THE AMYLOIDOSES

CHAPTER 107 THE AMYLOIDOSES Williams Hematology CHAPTER 107 THE AMYLOIDOSES JOEL N. BUXBAUM DANIEL R. JACOBSON Definition and History Etiology and Pathogenesis Mechanisms of Amyloid Formation Structure of Immunoglobulin-Related Amyloid Fibrils Clinical Features General Features Renal Involvement Cardiovascular Involvement Neurologic Involvement Carpal Tunnel Syndrome Gastrointestinal Involvement Respiratory Tract Involvement Musculoskeletal System Localized AL Bleeding Clinical […]

CHAPTER 106 PLASMA CELL MYELOMA

CHAPTER 106 PLASMA CELL MYELOMA Williams Hematology CHAPTER 106 PLASMA CELL MYELOMA BART BARLOGIE JOHN SHAUGHNESSY NIKHIL MUNSHI JOSHUA EPSTEIN Definition Etiology and Pathogenesis Animal Models Environmental Exposure Pathogenesis and Genetic Alterations Phenotype and Cytokines Myeloma Biology Clinical Features Pain Infections Nephropathy Extramedullary Disease Neuropathies Hyperviscosity Bleeding and Thrombosis Laboratory Features Initial Evaluation Hematologic Abnormalities […]

CHAPTER 105 ESSENTIAL MONOCLONAL GAMMOPATHY

CHAPTER 105 ESSENTIAL MONOCLONAL GAMMOPATHY Williams Hematology CHAPTER 105 ESSENTIAL MONOCLONAL GAMMOPATHY MARSHALL A. LICHTMAN Definition and History Occurrence Etiology and Pathogenesis Clinical Features Laboratory Features Plasma and Urinary Immunoglobulins Oligoclonal and Monoclonal Immunoglobulins Lymphocyte and Plasma Cell Phenotypes Course, Prognosis, and Therapy Chapter References Essential monoclonal gammopathy is defined by two key features: the […]