Archive | December 2011

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CHAPTER 54 HEMOLYTIC ANEMIA DUE TO INFECTIONS WITH MICROORGANISMS

CHAPTER 54 HEMOLYTIC ANEMIA DUE TO INFECTIONS WITH MICROORGANISMS Williams Hematology CHAPTER 54 HEMOLYTIC ANEMIA DUE TO INFECTIONS WITH MICROORGANISMS ERNEST BEUTLER Malaria Bartonellosis Babesiosis Other Infections Chapter References Hemolytic anemia is a prominent part of the clinical presentation of patients infected with organisms, such as the malaria parasites, Babesia, and Bartonella, that directly invade […]

CHAPTER 53 HEMOLYTIC ANEMIA DUE TO CHEMICAL AND PHYSICAL AGENTS

CHAPTER 53 HEMOLYTIC ANEMIA DUE TO CHEMICAL AND PHYSICAL AGENTS Williams Hematology CHAPTER 53 HEMOLYTIC ANEMIA DUE TO CHEMICAL AND PHYSICAL AGENTS ERNEST BEUTLER Arsenic Hydride Lead Copper Chlorates Miscellaneous Drugs and Chemicals Oxygen Insect, Spider, and Snake Venoms Heat Radiation Chapter References Arsenic, lead, copper, chlorates, and a variety of other chemicals can cause […]

CHAPTER 52 MARCH HEMOGLOBINURIA, SPORTS ANEMIA, AND SPACE ANEMIA

CHAPTER 52 MARCH HEMOGLOBINURIA, SPORTS ANEMIA, AND SPACE ANEMIA Williams Hematology CHAPTER 52 MARCH HEMOGLOBINURIA, SPORTS ANEMIA, AND SPACE ANEMIA ALLAN J. ERSLEV Etiology and Pathogenesis March Hemoglobinuria Sports Anemia Space Anemia Clinical and Laboratory Features Differential Diagnosis Therapy, Course, and Prognosis Chapter References Strenuous activities may cause traumatic damage to red cells, with subsequent […]

CHAPTER 51 MICROANGIOPATHIC HEMOLYTIC ANEMIA

CHAPTER 51 MICROANGIOPATHIC HEMOLYTIC ANEMIA Williams Hematology CHAPTER 51 MICROANGIOPATHIC HEMOLYTIC ANEMIA JOSE MARTINEZ Etiology and Pathogenesis Underlying Disorders Drugs Transplantation Vasculitis Localized Vascular Abnormalities Clinical Features Laboratory Findings Differential Diagnosis Therapy, Course, and Prognosis Chapter References The term microangiopathic hemolytic anemia refers to a group of clinical disorders characterized by the fragmentation of red […]

CHAPTER 50 TRAUMATIC CARDIAC HEMOLYTIC ANEMIA

CHAPTER 50 TRAUMATIC CARDIAC HEMOLYTIC ANEMIA Williams Hematology CHAPTER 50 TRAUMATIC CARDIAC HEMOLYTIC ANEMIA ALLAN J. ERSLEV Etiology and Pathogenesis Clinical Features Laboratory Features Differential Diagnosis Therapy, Course, and Prognosis Chapter References The abrasive effect on red cells of arteriosclerotic or stenotic cardiac valves is usually minimal, resulting at most in a mild, often compensated […]

CHAPTER 49 METHEMOGLOBINEMIA AND OTHER CAUSES OF CYANOSIS

CHAPTER 49 METHEMOGLOBINEMIA AND OTHER CAUSES OF CYANOSIS Williams Hematology CHAPTER 49 METHEMOGLOBINEMIA AND OTHER CAUSES OF CYANOSIS ERNEST BEUTLER Definition and History Etiology and Pathogenesis Toxic Methemoglobinemia Nadh-Diaphorase Deficiency Hemoglobins M Low-Oxygen Affinity Hemoglobins Sulfhemoglobin Mode of Inheritance Clinical Features Laboratory Features Toxic Methemoglobinemia Nadh-Diaphorase Deficiency Abnormal Hemoglobins Sulfhemoglobinemia Differential Diagnosis Therapy, Course, and […]

CHAPTER 48 HEMOGLOBINOPATHIES ASSOCIATED WITH UNSTABLE HEMOGLOBIN

CHAPTER 48 HEMOGLOBINOPATHIES ASSOCIATED WITH UNSTABLE HEMOGLOBIN Williams Hematology CHAPTER 48 HEMOGLOBINOPATHIES ASSOCIATED WITH UNSTABLE HEMOGLOBIN ERNEST BEUTLER Definition and History Etiology and Pathogenesis Mode of Inheritance Clinical Features Laboratory Features Differential Diagnosis Treatment, Course, and Prognosis Chapter References Mutations that cause destabilization of the hemoglobin tetramer are an uncommon cause of hemolytic anemia. In […]

CHAPTER 47 THE SICKLE CELL DISEASES AND RELATED DISORDERS

CHAPTER 47 THE SICKLE CELL DISEASES AND RELATED DISORDERS Williams Hematology CHAPTER 47 THE SICKLE CELL DISEASES AND RELATED DISORDERS ERNEST BEUTLER Definition and History Nomenclature The Sickle Cell Diseases Etiology and Pathogenesis Clinical Features Laboratory Features Diagnosis Therapy, Course, and Prognosis Prevention Sickle Cell Trait Definition and History Etiology and Pathogenesis Clinical Features Laboratory […]

CHAPTER 46 THE THALASSEMIAS

CHAPTER 46 THE THALASSEMIAS Williams Hematology CHAPTER 46 THE THALASSEMIAS DAVID J. WEATHERALL Definitions and History Different Forms of Thalassemia Etiology and Pathogenesis Genetic Control and Synthesis of Hemoglobin Globin Gene Clusters Molecular Basis of the Thalassemias Pathophysiology Imbalanced Globin-Chain Synthesis Persistent Fetal Hemoglobin Production and Cellular Heterogeneity Consequences of Compensatory Mechanisms for the Anemia […]

CHAPTER 45 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND OTHER RED CELL ENZYME ABNORMALITIES

CHAPTER 45 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND OTHER RED CELL ENZYME ABNORMALITIES Williams Hematology CHAPTER 45 GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCY AND OTHER RED CELL ENZYME ABNORMALITIES ERNEST BEUTLER Definition and History Etiology and Pathogenesis The Mechanism of Hemolysis Biochemical Genetics and Molecular Biology Other Enzyme Deficiencies Prevalence, Geographic Distribution, and Population Genetics Clinical Features Common Forms of […]