Leave a comment

Venezuelan Equine Encephalitis (VEE)

Venezuelan Equine Encephalitis (VEE)

Diagnosis

1.
Malaise, spiking fevers, rigors, severe HA, photophobia, myalgias

2.
N/V/D, cough, sore throat

3.
WBC: leukopenia and lymphopenia

4.
Virus isolation from serum, and throat swab specimens

5.
Neutralizing or IgG antibody in paired sera

6.
VEE specific IgM present in single serum sample indicates recent infection
History

1.
Weaponized in 1950’s & 1960’s by US
Pathophysiology

1.
VEE virus is arthropod-borne alphavirus endemic in northern South America, Trinidad, Central America, Mexico, Florida

2.
Acquired by mosquito bite

3.
Infective dose: 10-100 organisms

4.
Incubation: 1-5 d

5.
Duration: days to wks

6.
Lethality: low
Prevention

1.
Experimental vaccine, TC-83, with good results; single 0.5 ml SQ dose

2.
Alpha interferon, experimental, may be considered
Isolation/Decontamination

1.
Standard precautions for healthcare workers

2.
Human cases infectious for mosquitoes through 72 hrs

3.
Destroyed by heat (80 deg C for 30 mins) and standard disinfectants
Treatment

1.
Pts developing encephalitis need anticonvulsants

2.
Maintain fluid and electrolyte balance

3.
Ensure adequate ventilation

4.
Avoid secondary bacterial infections
Disposition

1.
Admit

2.
Screened room with residual insecticide for 5 d after onset

3.
Notify CDC & local health dept

* Material is taken from the PEPID database
* Copyrighted material – All Rights Reserved
* For more information visit http://www.pepid.com

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

%d bloggers like this: